ODCs

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2 OMIM references -
1 associated gene
7 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

1 OMIM reference -
1 associated gene
8 signs/symptoms

Early-onset generalized limb-onset dystonia

Dilated cardiomyopathy - hypergonadotropic hypogonadism


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	TOR1A	(0.75)	LMNA

Citations in the biomedical literature:

Early-onset generalized limb-onset dystonia		Dilated cardiomyopathy - hypergonadotropic hypogonadism
	Synonym(s): - DYT1 - Dystonia musculorum deformans - EOTD - Early-onset generalized torsion dystonia - Early-onset primary dystonia - Early-onset torsion dystonia - Idiopathic dystonia - Idiopathic torsion dystonia - Oppenheim dystonia		Synonym(s): - Cardiogenital syndrome - Malouf syndrome - Najjar syndrome

	Classification (Orphanet): - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare cardiac disease - Rare endocrine disease - Rare genetic disease - Rare infertility

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: adolescence / young Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive

	External references: 2 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Autosomal recessive inheritance

Early-onset generalized limb-onset dystonia		Dilated cardiomyopathy - hypergonadotropic hypogonadism
	Very frequent - Abnormal gait - Autosomal dominant inheritance - Hypertonia / spasticity / rigidity / stiffness - Movement disorder - Muscle anomalies Frequent - Abnormal cry / voice / phonation disorder / nasal speech		Very frequent - Abnormal / polycystic ovaries - Broad nose / nasal bridge - Cardiomyopathy / hypertrophic / dilated - Decreased body hair / axillar / pubic hairlessness - Late puberty / hypogonadism / hypogenitalism - Precocious puberty - Ptosis